ABSTRACT
El síndrome de Guillain-Barré constituye una entidad de etiología diversa, que se caracteriza por debilidad muscular aguda, simétrica, ascendente y progresiva, y es una de las polineuropatías adquiridas más frecuentes en la infancia. Entre los diagnósticos diferenciales, deben considerarse las neuropatías producidas por metales pesados, mercurio y plomo, y metaloides, como el arsénico, plaguicidas organofosforados y el tetracloruro de carbono.Se presenta a un paciente de 14 años con diagnóstico de síndrome de Guillain-Barré sin respuesta al tratamiento convencional con gammaglobulina. Considerando otras etiologías, se sospechó neuropatía producida por metales pesados, y se confirmó intoxicación por mercurio.El objetivo de esta presentación es concientizar a los pediatras acerca del impacto de los tóxicos ambientales en la salud infantil para realizar un diagnóstico precoz pesquisando datos clave a través de la historia clínica ambiental
Guillain-Barré syndrome is an entity of diverse etiology, characterized by acute, symmetric, ascending and progressive muscle weakness, being one of the most frequent acquired polyneuropathies in childhood. Neuropathies produced by heavy metals, mercury and lead, and metalloids, such as arsenic, organophosphorus pesticides and carbon tetrachloride, should be considered among the differential diagnoses.We present a 14-year-old patient with a presumptive diagnosis of Guillain-Barré syndrome without response to conventional treatment with gamma globulin. Considering other etiologies, heavy metal neuropathy was suspected, and mercury poisoning was confirmed.The aim of this presentation is to make pediatricians aware about the impact of environmental toxic agents on children's health in order to make an early diagnosis by researching key data through the environmental clinical history.
Subject(s)
Humans , Male , Adolescent , Mercury Poisoning, Nervous System/diagnosis , Polyneuropathies , Heavy Metal Poisoning, Nervous System/drug therapy , Environmental Exposure/adverse effectsABSTRACT
La presente publicación describe las instrucciones para el registro y codificación de las actividades de la estrategia sanitaria nacional de atención a personas afectadas por la contaminación con metales pesados y otras sustancias químicas. El registro de los datos generales se sigue las indicaciones pertinentes y no presenta características especiales. Asimismo, incluye los ítems diagnóstico motivo de consulta, tipo de diagnóstico y Lab que presentan algunas particularidades
Subject(s)
International Classification of Diseases , Clinical Coding , Poisoning/prevention & control , Health Statistics , Data Interpretation, Statistical , Heavy Metal Poisoning, Nervous System , Preventive Health Services , Registries , Toxic Substances , House Calls , PeruABSTRACT
No presente trabalho é relatado caso de intoxicação crônica por cobre (ICC) ocorridos em rebanho ovino pastoreados em pomar de videiras, na serra Gaúcha; suplementados com bagaço de uva e concentrado. O pomar era aspergido anualmente com solução de sulfato de cobre a 2% e teve seu solo adubado com cama aviária. Os ovinos mostraram andar cambaleante, icterícia intensa das mucosas e urina escura, dos quais foram a óbito oito animais, correspondendo a 57% do total do rebanho. Os sinais clínicos e lesões histológicas foram características da ICC. A dosagem de Aspartato Aminotrasferase (AST) no soro dos seis ovinos remanescentes variou de 48,8 a 403,3 UI/L. O nível de cobre encontrado na cama aviária, bagaço de uva, pastagem e concentrado foram de 637, 158, 86 e 18 mg/kg respectivamente. Conclui-se que os óbitos ocorreram devido ao alto nível de cobre encontrado na pastagem, bagaço de uva e concentrado administrado aos animais. Sugere-se também, o risco de dano ambiental no uso de cama aviária na adubação de pastagem, assim como a inadequação da alimentação de ovinos com bagaço de uva.
This work describe dead due to chronic copper poisoning (CCP) that occurred in a flock of sheep grazed under grape orchard, located at the hilly area of southern Brazil; supplemented with concentrate and crushing grapes husks. The orchard was annually sprayed with 2 per cent copper sulphate and the ground fertilised with poultry litter. The sheep showed depression, jaundice and hemoglobinuria. Fourteen sheep died, representing 57 per cent of the flock. The clinical sign, necropsy and microscopic findings were typical of CCP. The serum level of aspartate aminotrasferase (AST) of remain six sheep, varied from 48.8 to 403.3 IU/L. The cooper level found in the poultry litter, crushing grapes husks, grass and concentrate were 637, 158, 86 and 18 mg/kg, respectively. It is concluded that the sheep losses occurred due to the high level of copper found in the pasture, crushing grapes husks and concentrate fed to the animals. It is also suggested, the environmental risk of poultry litter as fertiliser of sheep pasture as well as the use of crushing grapes husks as sheep supplemental feeding.
Subject(s)
Copper/toxicity , Heavy Metal Poisoning, Nervous System/mortality , Pasture/adverse effects , Sheep , VitisABSTRACT
Study of plant roots and the diversity of soil micro biota, such as bacteria, fungi and microfauna associated with them, is important for understanding the ecological complexities between diverse plants, microbes, soil and climates and their role in phytoremediation of contaminated soils. The arbuscular mycorrhizal fungi (AMF) are universal and ubiquitous rhizosphere microflora forming symbiosis with plant roots and acting as biofertilizers, bioprotactants, and biodegraders. In addition to AMF, soils also contain various antagonistic and beneficial bacteria such as root pathogens, plant growth promoting rhizobacteria including free-living and symbiotic N-fixers, and mycorrhiza helping bacteria. Their potential role in phytoremediation of heavy metal (HM) contaminated soils and water is becoming evident although there is need to completely understand the ecological complexities of the plant-microbe-soil interactions and their better exploitation as consortia in remediation strategies employed for contaminated soils. These multitrophic root microbial associations deserve multi-disciplinary investigations using molecular, biochemical, and physiological techniques. Ecosystem restoration of heavy metal contaminated soils practices need to incorporate microbial biotechnology research and development. This review highlights the ecological complexity and diversity of plant-microbe-soil combinations, particularly AM and provides an overview on the recent developments in this area. It also discusses the role AMF play in phytorestoration of HM contaminated soils, i.e. mycorrhizoremediation.
Subject(s)
Biodegradation, Environmental , Heavy Metal Poisoning, Nervous System , Metabolism , Plant Roots , Metabolism , Microbiology , Soil Microbiology , Soil Pollutants , PharmacokineticsABSTRACT
Neste trabalho, a autora faz uma revisão bibliográfica sobre intoxicação por zinco, um metal amplamente presente em diversos ambientes industriais. O zinco tem efeitos tópicos e sistêmicos sobre o organismo humano, sendo que, muitas vezes, estes efeitos não são correlacionados à este metal, pois nos ambientes industriais, geralmente há uma associação de metais e outras substâncias. Neste trabalho são citados: a composição química, população exposta, efeitos tóxicos sobre o organismo, quadro clínico da intoxicação pelo zinco. Há uma correlação entre a revisão bibliográfica e a amostra de pacientes atendidos no ambulatório de Saúde Ocupacional do Hospital Universitário Antonio Pedro. A autora visa através de revisão bibliográfica fornecer dados à respeito do zinco, seus efeitos correlacionado à saúde do trabalhador, o uso do zinco na indústria, a população exposta, quadro clínico da intoxicação, tratamento e prevenção.